![]() Indigo Carmine is in a structural structure in water. Indigo Carmine is a food colorant with the code E 132. ![]() Indigo Carmine is contraindicated in patients who have previously experienced an adverse reaction following its use Appearance time and elimination are delayed following intramuscular injection. Larger quantities are necessary when intramuscular injection is employed. The biological half-life is 4 to 5 minutes following intravenous injection. Indigo Carmine is excreted largely by the kidneys, retaining its blue color during passage through the body.Įlimination of the dye begins soon after injection, appearing in the urine within 10 minutes in average cases. Indigo carmine can also be used ex vivo to stain certain specimens, differentiate between benign and malignant lesions, and help stage and diagnose certain types of cancers.Īn organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. Upon intravenous administration, indigotindisulfonate is filtered rapidly by the kidneys from the blood and colors the urinary tract which enables the urinary tract to be seen during surgery. Indigo carmine is the sodium salt form of indigotindisulfonate, a synthetic blue dye and food colorant derived from indigo, that can be used as a stain in medical imaging and as a redox and pH indicator. Indigo carmine contains an indigo carmine(2-). Indigo carmine has a role as a food colouring, a histological dye and a two-colour indicator. Indigo carmine is an indicator at pH 11.5-14, changing from blue to yellow. Indigo carmine is an organic sodium salt resulting from the formal condensation of indigo carmine (acid form) with two equivalents of sodium hydroxide. Indigo carmine has been used to diagnose Barrett’s esophagus, evaluate villous atrophy, diagnose and discriminate polypoid and non-polypoid lesions in the colon, and diagnose gastric adenoma and cancer. Generally used at a concentration around 0.2%, indigo carmine stain is useful as a screening method for diagnosing minute lesions, to differentiate between benign and malignant lesions, as well as to facilitate application of ME to observe and analyze the surface structure of a lesion, delineate boundaries of early stage malignant lesions and estimate the invasion depth of cancer. However, the dye can cause a potentially dangerous increase in blood pressure in some cases.Īlthough not absorbed by the cells, indigo carmine stain, sprayed onto regions of interest, highlights the topography of the mucosal surface with its blue coloring. This enables structures of the urinary tract to be seen in the surgical field, and demonstrate if there is a leak. The dye is filtered rapidly by the kidneys from the blood, and colors the urine blue. In urologic surgery, intravenous injection of indigo carmine is often used to highlight portions of the urinary tract. In obstetric surgery, indigo carmine solutions are sometimes employed to detect amniotic fluid leaks. Indigo carmine is also used as a dye in the manufacturing of capsules. Indigo carmine also detects superoxide, an important distinction in cell physiology. This reaction has been shown not to be specific to ozone, however: Another use is as a dissolved ozone indicator through the conversion to isatin-5-sulfonic acid. Indigo carmine is also a redox indicator, turning yellow upon reduction. Indigo carmine in a 0.2% aqueous solution is blue at pH 11.4 and yellow at 13.0. Indigo carmine is approved for use as a food colorant in the U.S and E.U. Indigo carmine, or 5,5′-indigodisulfonic acid sodium salt, is an organic salt derived from indigo by aromatic sulfonation, which renders the compound soluble in water.
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